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KMID : 0043320060290100921
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Archives of Pharmacal Research
2006 Volume.29 No. 10 p.921 ~ p.927
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Preparation of Prolonged Release Clarithromycin Microparticles for Oral Use and Their In Vitro Evaluation
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Genc Lutfi
Demirel Muzeyyen
Yazan Yasemin
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Abstract
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Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of castingdrying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.
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KEYWORD
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Prolonged release, Microparticle, Clarithromycin, Eudragit RL 100 and RS 100, Spray-drying, Casting-drying
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